Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of Lambert-Eaton myasthenic syndrome with exacerbation of respiratory failure triggered by acute myocardial infarction

Tomohiro Uemura, M.D.1)2), Jun Sawada, M.D., Ph.D.2), Ikkei Ohashi, M.D.1), Bungo Hirose, M.D.1)3) and Rika Yamauchi, M.D., Ph.D.1)3)

1) Department of Neurology, Asahikawa Medical University Hospital
2) Department of Neurology, Sunagawa City Medical Center
3) Department of Neurology, National Hakone Hospital

The patient, a 58-year-old man, experienced weakness of the proximal muscles in both lower extremities, and Lambert-Eaton myasthenic syndrome and small cell carcinoma of unknown primary origin were diagnosed. He received symptomatic treatment for myasthenia and radiochemotherapy for small cell carcinoma; once this regimen, the myasthenic symptoms improved. However, acute myocardial infarction occurred, after which type II respiratory failure developed, and the patient required ventilator management with tracheal intubation. Acute-phase treatment, such as plasma exchange, intravenous immune globulin therapy, and methylprednisolone pulse therapy, and intensification of symptomatic treatment allowed for extubation, and eventually the patient was able to walk independently. According to electrophysiological examination, compound muscle action potentials were larger at discharge than at the time of exacerbation.
Full Text of this Article in Japanese PDF (1562K)

(CLINICA NEUROL, 63: 363|368, 2023)
key words: Lambert-Eaton myasthenic syndrome, acute myocardial infarction, type II respiratory failure, methylprednisolone pulse therapy, repetitive nerve stimulation

(Received: 16-Feb-23)