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• Vol.62 No.7
• CLINICA NEUROL, 62: 558−562, 2022
• Vol.62 No.7 contents

Case Report

A case of polyneuropathy after COVID-19 vaccine

Mari Iseki, M.D.¹⁾, Hiroki Nakayama, M.D.¹⁾, Mutsufusa Watanabe, M.D., Ph.D.¹⁾, Ayumi Uchibori, M.D., Ph.D.²⁾, Atsuro Chiba, M.D., Ph.D.²⁾ and Saneyuki Mizutani, M.D., Ph.D.¹⁾

¹⁾ Department of Neurology, Tokyo Metropolitan Bokutoh Hospital
²⁾ Department of Neurology, Kyorin University Hospital

A 43-year-old-woman developed paresthesia, weakness of limbs, dysphagia and deep sensory impairment 12 days after vaccination of Pfizer COVID-19 vaccine. Her deep tendon reflexes were absent and cerebrospinal fluid showed normal cell counts and protein level. Anti-ganglioside antibodies were negative, and F wave frequency was decreased in nerve conduction studies. We diagnosed her as immune mediated polyneuropathy caused by COVID-19 vaccine, and plasma exchange improved her symptoms. Compared with Guillain-Barré syndrome and polyneuropathy following COVID-19 infection and COVID-19 vaccination, deep sensory impairment was the most characteristic of this case. We supposed that non-antigen specific mechanism played an important role in the pathogenesis of this case.
Full Text of this Article in Japanese PDF (484K)

(CLINICA NEUROL, 62: 558−562, 2022)
key words: COVID-19, SARS-CoV-2, vaccination, polyneuropathy, Guillain-Barré syndrome

(Received: 10-Feb-22)