Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of cardioembloic stroke with wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome

Sho Wako, M.D.1), Sono Toi, M.D., Ph.D.1), Takafumi Mizuno, M.D.1), Ayako Nishimura, M.D.1), Kentaro Ishizuka, M.D., Ph.D.1) and Kazuo Kitagawa, M.D., Ph.D.1)

1) Department of Nerurology, Tokyo Women's Medical University

Here, we report a case of an 85-year-old man who presented sudden onset of diplopia, dysarthria, and gait disturbance. On admission, he exhibited bilateral adduction palsy, convergence palsy, and binocular exotropia in the forward gaze showing wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome. He had a history of chronic nonvalvular atrial fibrillation. DWI-MRI revealed acute ischemic lesions in the paramedian pontine tegmentum, lower midbrain, both cerebellar hemispheres, and left frontal cortex. He was thus diagnosed with an acute phase of cardioembolic stroke. Subsequently, the right eye adduction palsy in the forward gaze was slightly improved, but other eye movement disorders persisted during discharge from the hospital. The pathology was suspected to involve bilateral damages to both medial longitudinal fasciculus and the paramedian pontine reticular formation. WEBINO syndrome was not only ascribed to lacunar infarction and large artery atherosclerosis but also cardioembolic stroke. The presence of other non-eye symptoms and multiple ischemic lesions could be the characteristics of WEBINO syndrome following cardioembolic stroke.
Full Text of this Article in Japanese PDF (3114K)

(CLINICA NEUROL, 62: 541−545, 2022)
key words: cardioembolic stroke, WEBINO (wall-eyed bilateral internuclear ophthalmoplegia) syndrome, PPRF (paramedian pontine reticular formation), MLF (medial longitudinal fasciculus), internuclear ophthalmoplegia

(Received: 14-Sep-21)