Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of paraneoplastic sensory neuronopathy with anti-Hu antibody associated with large cell neuroendocrine carcinoma of the endometrium

Rina Kato, M.D.1), Naoto Aoyama, M.D.1), Saneyuki Mizutani, M.D., Ph.D.1), Masahiro Warabi, M.D., Ph.D.2), Takahiro Kasamatsu, M.D., Ph.D.3) and Hiroto Hujigasaki, M.D., Ph.D.1)

1) Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital
2) Department of Pathology, Tokyo Metropolitan Bokutoh Hospital
3) Department of Obstetrics and Gynecology, Tokyo Metropolitan Bokutoh Hospital

An 81-year-old woman was admitted to our hospital due to paresthesia of the extremities and difficulty in walking for three months. She underwent a total hysterectomy and bilateral salpingo-oophorectomy for large cell neuroendocrine carcinoma (LCNEC) of the endometrium seven months before the admission. The serum levels of neuron specific enolase (NSE) reduced after the surgery. She showed numbness of her limbs, disturbance of vibration, areflexia and autonomic dysfunction. Nerve conduction studies showed sensory dominant sensory neuronopathy. CT scan of her abdomen and pelvis revealed the recurrence of LCNEC of the endometrium. The serum levels of NSE was elevated and anti-Hu antibody was also positive. Other laboratory test, including autoantibodies were unremarkable. We diagnosed her as paraneoplastic sensory neuronopathy associated with postoperative recurrence of LCNEC of the endometrium. Here we show a clinical picture of anti-Hu positive paraneoplastic neurological syndrome with LCNEC of the endometrium.
Full Text of this Article in Japanese PDF (5542K)

(CLINICA NEUROL, 60: 441−445, 2020)
key words: paraneoplastic neurological syndrome, anti-Hu antibody, large cell neuroendocrine carcinoma of the endometrium, sensory neuronopathy

(Received: 4-Nov-19)