Rinsho Shinkeigaku (Clinical Neurology)

Case Report

Confusional migraine in a young adult female: Is it a subtype of migraine with aura?

Yuya Kano, M.D.1), Takuya Oguri, M.D., Ph.D.1), Hanako Sugiyama, M.D.2), Shoji Kikui, M.D., Ph.D.2), Takao Takeshima, M.D., Ph.D.2) and Hiroyuki Yuasa, M.D., Ph.D.1)

1)Department of Neurology, Tosei General Hospital
2)Department of Neurology, Tominaga Hospital

A 22-year-old female was admitted to our hospital due to acute onset of severe headache, confusion, and deterioration of consciousness. Results of initial examinations did not suggest cerebrovascular diseases, encephalitis, or nonconvulsive status epilepticus. Over the next several weeks, her level of consciousness fluctuated in parallel with the severity of headache. The electroencephalogram, recorded during a symptomatic episode, showed lack of posterior dominant rhythm, and the single-photon emission CT (SPECT) also revealed a decrease in cerebral blood flow predominantly in the occipital lobes. Administration of sodium valproate and topiramate, recommended as treatment for migraine, dramatically ameliorated her headache and consciousness. Although this was an adult-onset case, her symptoms and clinical course were similar with the diagnosis of ICHD-3-unlisted confusional migraine rather than other listed subtypes of migraine with aura. Further accumulation of similar adult-onset cases is necessary to clarify the nature of this illness.
Full Text of this Article in Japanese PDF (1697K)

(CLINICA NEUROL, 60: 46|50, 2020)
key words: migraine with brainstem aura, confusional migraine, sodium valproate, topiramate, ICHD-3

(Received: 24-Jun-19)