Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A women with aplastic anemia developed chronic inflammatory demyelinating polyneuropathy

Masaaki Abe, M.D., Ph.D.1), Fumitaka Shimizu, M.D., Ph.D.2), Munehisa Suzukawa, M.D.3), Toshihiko Maeda, M.D., Ph.D.2), Masatoshi Omoto, M.D., Ph.D.2) and Takashi Kanda, M.D., Ph.D.2)

1)Department of Neurology, Tokuyama Central Hospital
2)Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
3)Department of Haematology, Shuto General Hospital

A 66-year-old female developed chronic inflammatory demyelinating polyneuropathy (CIDP) one year after the diagnosis of aplastic anemia. High-dose intravenous immunoglobulin (IVIg) therapy, followed by IVIg maintenance therapy, rapidly improved her weakness and hyperesthesia in four extremities. In addition, pancytopenia caused by aplastic anemia also improved following IVIg treatment in parallel. This is the first report to show the co-existence of CIDP and aplastic anemia, and a common pathomechanism may be present in these two rare autoimmune disorders.
Full Text of this Article in Japanese PDF (595K)

(CLINICA NEUROL, 59: 818|822, 2019)
key words: aplastic anemia, chronic inflammatory demyelinating polyneuropathy, immunoglobulin

(Received: 18-Apr-19)