Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

A case of neuromyelitis optica with varicella zoster virus meningitis during mitoxantrone treatment

Hitoshi Nakano, M.D.1), Rie Motoyama, M.D.1), Keiko Tanaka, M.D.2) and Masami Tanaka, M.D.1)

1)Multiple Sclerosis Center, Utano National Hospital
2)Department of Neurology, Kanazawa Medical University

A 36-year-old woman with neuromyelitis optica had been treated with steroids for the prevention of relapse. However, her treatment was not effective and she showed adverse effects such as diabetes mellitus, osteoporosis, compression fractures, and Pneumocystis carinii pneumonia. Therefore, we started her on mitoxantrone treatment. After five courses of mitoxantrone injection, she developed a herpes zoster infection in her thigh followed by aseptic meningitis. PCR for varicella zoster virus (VZV)-DNA was positive in the cerebrospinal fluid. The mechanisms that caused VZV reactivation by mitoxantrone are not known. Opportunistic herpes virus reactivation may occur easily with increasing use of immunosuppressive drugs for both neuromyelitis optica and multiple sclerosis. These drugs must be used under careful supervision.
Full Text of this Article in Japanese PDF (256K)

(CLINICA NEUROL, 51: 703|705, 2011)
key words: neuromyelitis optica, mitoxantrone, varicella zoster virus, meningitis, opportunistic infection

(Received: 27-Dec-10)