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• Vol.64 No.4
• CLINICA NEUROL, 64: 292−295, 2024
• Vol.64 No.4 contents

Case Report

A case of myasthenia gravis with coexistence of anti-acetylcholine receptor antibodies and anti-P/Q-type VGCC antibodies

Yuki Takeda, M.D.^1）, Yoshikatsu Noda, M.D., Ph.D.^2）, Naohiko Seike, M.D., Ph.D.^1） and Hiroyuki Ishihara, M.D., Ph.D.^1）

¹⁾Division of Neurology, Kakogawa Central City Hospital
²⁾Nakata Clinic

A 79-year-old woman who presented ptosis and dysphagia were admitted to our hospital. Anti-acetylcholine receptor antibodies and anti-P/Q-type VGCC antibodies were both positive. Electrophysiological examination showed postsynaptic pattern which supported myasthenia gravis. She did not meet the diagnostic criteria for Lambert-Eaton myasthenic syndrome (LEMS). In cases which these antibodies coexist, careful electrophysiological evaluation is required for the diagnosis. In addition, although anti-P/Q-type VGCC antibodies have been specific to LEMS, patients with these antibodies represent various symptoms other than LEMS. Low and middle titer of the antibodies may be not specific to LEMS.
Full Text of this Article in Japanese PDF (252K)

(CLINICA NEUROL, 64: 292−295, 2024)
key words: anti acetylcholine receptor antibodies, anti-P/Q-type VGCC antibodies, myasthenia gravis, myasthenia gravis Lambert-Eaton overlap syndrome(MLOS)

(Received: 2-Nov-23)