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• Vol.64 No.4
• CLINICA NEUROL, 64: 272−279, 2024
• Vol.64 No.4 contents

Original Article

Clinical characteristics of seizure-predominant autoimmune encephalitis and utility of anti-neuronal antibody scores for early treatment

Masanobu Tanemoto, M.D.^1）, Syuuichirou Suzuki, M.D., Ph.D.^1）, Kazuki Yokokawa, M.D., Ph.D.^1）,Taro Saito, M.D., Ph.D.^1）, Naotoshi Iwahara, M.D., Ph.D.^1）, Reiko Tsuda, M.D.^1）, Osamu Watanabe, M.D., Ph.D.^2）,Yukitoshi Takahashi, M.D., Ph.D.^3）, Makoto Yoneda, M.D., Ph.D.^4） and Shin Hisahara, M.D., Ph.D.^1）

¹⁾Department of Neurology, Sapporo Medical University, School of Medicine
²⁾Department of Neurology, Kagoshima City Hospital
³⁾Department of Clinical Research, NHO, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
⁴⁾Faculty of Nursing and Social Welfare Sciences, Fukui Prefectural University

We analyzed 20 patients diagnosed with autoimmune neurological diseases with seizure predominance. In these patients, we examined the usefulness of Antibody Prevalence in Epilepsy and Encephalopathy (APE²) score and Antibodies Contributing to Focal Epilepsy Signs and Symptoms (ACES) score in autoimmune encephalitis (AE) for facilitating early treatment. APE2 score was positive in 19 of 20 patients. ACES score was positive in 15 of 20 patients, and 4 of 5 of the patients with negative ACES score did not have AE. Comprehensive assessment including the use of the above scores is desirable in the early stage of AE.
Full Text of this Article in Japanese PDF (1285K)

(CLINICA NEUROL, 64: 272−279, 2024)
key words: autoimmune encephalitis, epilepsy, APE² score, ACES score, antibody

(Received: 28-Dec-23)