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• Vol.63 No.11
• CLINICA NEUROL, 63: 715−724, 2023
• Vol.63 No.11 contents

Invited Review

The significance of autoantibodies against nodal and paranodal proteins in autoimmune nodopathies

Hidenori Ogata, M.D., Ph.D.¹⁾

¹⁾ Department of Neurology, Kyushu University Hospital

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is recognized as a syndrome caused by multiple pathologies. Since the 2010s, it has been clarified that autoantibodies against membranous proteins localized in the nodes of Ranvier and paranodes are positive in subsets of CIDP patients, leading to proposing a new disease concept called autoimmune nodopathies, which is independent of CIDP, in the revised international CIDP guidelines. This article reviews the significance of these autoantibodies, especially anti-neurofascin 155 and anti-contactin 1 antibodies, which have been the most prevalent and achieved a higher degree of consensus.
Full Text of this Article in Japanese PDF (2635K)

(CLINICA NEUROL, 63: 715−724, 2023)
key words: autoimmune nodopathy, autoantibody, node of Ranvier, neurofascin, contactin 1

(Received: 30-Apr-23)