Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of primary central nervous system lymphoma with marked cauda equina enlargement

Takashi Jono, M.D.1), Shigeki Yamaguchi, M.D., Ph.D.1), Takeshi Ito, M.D.1), Mei Sasaki, M.D.1), Yoichi Kanatsuka, M.D.1) and Ryuichiro Hayashi, M.D., Ph.D.1)

1) Department of Neurology, Yokohama Municipal Hospital

An 80-year-old woman presented with subacute right lower limb pain and bilateral lower limb weakness. MRI of the spine showed marked cauda equina enlargement with contrast enhancement. Cerebrospinal fluid (CSF) examination showed elevated cell count, decreased glucose, and elevated protein. Cytology of the CSF showed class V, which together with B-cell clonality by flow cytometry, led to the diagnosis of primary central nervous system lymphoma (PCNSL). The patient was treated with steroid, radiation, and chemotherapy. Despite the reduction in lesion size, her neurological symptoms revealed no improvement. PCNSL with cauda equina lesions are rare and often require highly invasive cauda equina biopsy for diagnosis. In recent years, some studies reported useful CSF biomarkers, but they may have some problems. Therefore, as in this case, the combination of cytology, flow cytometry and, CSF biomarkers could be a substitute method for invasive biopsies, and contribute to the early treatment of PCNSL.
Full Text of this Article in Japanese PDF (2284K)

(CLINICA NEUROL, 63: 31|36, 2023)
key words: cauda equina enlargement, primary central nervous system lymphoma, flow cytometry, cytology of CSF, biomarkers

(Received: 1-Sep-22)