Rinsho Shinkeigaku (Clinical Neurology)

Case Report

Probable rheumatoid meningitis complicated by cryptococcal meningitis: A case report

Takafumi Okusa, M.D.1)2), Hiroshi Shoji, M.D.1), Shuichi Oguri, M.D.3) and Teruaki Nakano, M.D.4)

1) Department of Neurology, St. Mary's Hospital, Fukuoka
2) Present address: Department of Obstetrics and Gynecology, Kurume University Hospital, Fukuoka
3) Department of Radiology, St. Mary's Hospital, Fukuoka
4) Department of Rheumatology, St. Mary's Hospital, Fukuoka

We report a case of rheumatoid meningitis complicated with cryptococcal meningitis in a 59-year-old female with rheumatoid arthritis. Migraine symptoms were followed by abnormal behavior, and the patient was admitted with fever and headache. On admission, her cerebrospinal fluid (CSF) contained 115 cells/µl, a protein content of 95 mg/dl, and a sugar level of 47 mg/dl; Her serum anti-cyclic citrullinated peptide (CCP) antibody value was high (174 U/ml), and a brain MRI showed enhanced gadolinium lesions in the cerebral/cerebellar pia mater and subarachnoid space, etc. Probable rheumatoid meningitis was clinically diagnosed, and a prednisolone (PSL) pulse was started. Several days later, a CSF culture test was positive for Cryptococcus neoformans, and the antigen titer was 128-fold. Liposomal-amphotericin B (L-AMB) was started for cryptococcal meningitis, combined with three PSL pulses for rheumatoid meningitis. After about 4 weeks, the number of CSF cells and anti-CCP antibodies decreased rapidly. At 2 months after the onset, the meningitis recurred. The MRI contrast lesions reappeared, and the CSF cells increased to 24/µl. Serum and CSF anti-CCP antibodies increased at the time of recurrence, but the cryptococcal antigen titer decreased. Thus, we concluded that the rheumatoid meningitis mainly involved the pathogenesis of both types of meningitis. The number of PSL pulses was limited to four. Post-perioral therapy was avoided. Methotrexate was continued for the rheumatoid meningitis, fluconazole was continued for the cryptococcal meningitis, and neither type of meningitis has recurred.
Full Text of this Article in Japanese PDF (3360K)

(CLINICA NEUROL, 60: 429−433, 2020)
key words: rheumatoid meningitis, cryptococcal meningitis, brain pia mater and subarachnoid space, anti-cyclic citrullinated peptide antibody

(Received: 4-Nov-19)