Rinsho Shinkeigaku (Clinical Neurology)

Case Report

The duration of antibiotic therapy in bacterial meningitis with pyogenic ventriculitis

Ryo Tokimura, M.D.1), Masahiro Iguchi, M.D.1), Eiich Ito, M.D.2), Takenobu Murakami, M.D., Ph.D.1) and Yoshikazu Ugawa, M.D., Ph.D.3)

1)Department of Neurology, Fukushima Medical University
2)Department of Neurology, Fukushima National Hospital
3)Department of Neuro-regeneration, Fukushima Medical University

A 68-year-old man visited our hospital emergency department with consciousness disturbance. He was diagnosed as bacterial meningitis with septic shock, and initial empirical antibacterial therapy was initiated immediately. Streptococcus pneumoniae. was cultured from the cerebrospinal fluid (CSF), and brain MRIs showed pyogenic ventriculitis. Even though CSF findings improved, he was still in coma and finally died with pneumonia. It is unknown how pyogenic ventriculitis affects the course of bacterial meningitis. We analyzed total 11 inpatients with bacterial meningitis associated with or without the pyogenic ventriculitis, including the present patient, in our hospital. Severity of clinical symptoms and CSF findings might determine the duration of antimicrobial administration, regardless of whether pyogenic ventriculitis existed or not.
Full Text of this Article in Japanese PDF (525K)

(CLINICA NEUROL, 59: 133|138, 2019)
key words: pyogenic ventriculitis, bacterial meningitis, antimicrobial treatment, streptococcus pneumoniae, MRI

(Received: 15-Aug-18)