Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of hemichorea associated with lung adenocarcinoma

Yoko Mori, M.D.1), Saneyuki Mizutani, M.D., Ph.D.1), Daisuke Ono, M.D.1), Keiko Ichinose, M.D.1), Mutsufusa Watanabe, M.D., Ph.D.1) and Takanori Yokota, M.D., Ph.D.2)

1)Division of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital
2)Department of Neurology and Neurological Science, Tokyo Medical and Dental University

An 81-year-old woman admitted to our hospital due to involuntary movement on her right extremities. Laboratory tests, including autoantibodies, were unremarkable and only age related changes were observed on brain MRI. Chest CT revealed lung adenocarcinoma. She was diagnosed as having paraneoplastic chorea. After removal of the tumor, her chorea was dramatically improved. One year after the operation, abnormal high intensity lesions were seen in bilateral caudate nuclei and globus pallidus on MRI. A part of the left caudate nucleus was enhanced by gadolinium. Here we show a clinical picture and neuroradiological findings of paraneoplastic chorea associated with lung adenocarcinoma.
Movie legends
Movie 1@Involuntary movements (hemichorea) on admission.
The movie shows hemichorea on her right extremities. Hemichorea worsens with arm elevation.
Movie 2@Hemichorea 6 months after the operation.
The movie shows the improvement of hemichorea after the operation.
Full Text of this Article in Japanese PDF (573K)

(CLINICA NEUROL, 58: 430|434, 2018)
key words: Paraneoplastic neurologic syndrome, chorea, lung adenocarcinoma, MRI, dopamine transporter

(Received: 16-Jan-18)