Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

Parkinson's disease associated with SAPHO syndrome: a case report

Takashi Ando, M.D.1)2), Amane Araki, M.D.1), Shinichi Terao, M.D.1) and Masahisa Katsuno, M.D.2)

1)Department of Neurology, Kasugai Municipal Hospital
2)Department of Neurology, Nagoya University Graduate School of Medicine

A 77-year-old woman with Parkinson's disease presented with left chest pain. Physical examination revealed tenderness at her second left sternocostal joint. There was no skin rash. Chest CT revealed hyperostosis of the sternocostal joint, and cervical MRI showed vertebral osteosclerosis and osteolysis. 99mTc-MDP bone scintigraphy showed an increased activity in the sternocostal joint and vertebral column. The patient was diagnosed with SAHPO syndrome according to the diagnostic criteria. Her chest pain was relieved after oral administration of nonsteroidal antiinflammatory drugs. Although pain is a common non-motor symptom of Parkinson's disease, chest pain is relatively rare, according to a previous reports. When patients with Parkinson's disease complain of chest pain, physicians should make an appropriate differential diagnosis after excluding emergent cardiovascular disease. To the best of our knowledge, this is the first report of Parkinson's disease associated with SAPHO syndrome. The relationship between the two diseases is unclear. However, peripheral inflammation is known to exacerbate ongoing neuronal damage in neurodegenerative diseases, such as Parkinson's disease. Therefore, systemic inflammation of SAPHO syndrome may affect the disease course of Parkinson's disease.
Full Text of this Article in Japanese PDF (305K)

(CLINICA NEUROL, 58: 332|334, 2018)
key words: SAPHO syndrome, Parkinson's disease, pain, inflammation

(Received: 4-Oct-17)