Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of neurolymphomatosis presented as cauda equine syndrome accompanied with M-proteinemia

Hirofumi Konishi, M.D.1), Yoshiharu Taguchi, M.D., Ph.D.1), Mamoru Yamamoto, M.D.1), Takamasa Nukui, M.D., Ph.D.1), Nobuhiro Dougu, M.D., Ph.D.1) and Yuji Nakatsuji, M.D., Ph.D.1)

1)Department of Neurology, Toyama University Hospital

A 63-year-old man developed a syndrome of cauda equine, with the numbness which is a left lower extremity from the left buttocks, weakness of left leg, and a dysfunction of bladder and bowel. Enhanced MRI revealed the enhancement of lower cauda equine, and a nerve conduction test revealed decreased F-wave persistency in the tibial nerve and increased F-wave latency in the peroneal nerve on the both sides. M-proteinemia was admitted and myeloma was suspected. By a biopsy of a vertebral arch, we diagnosed with diffuse large B-cell lymphoma. We treated with dexamethasone and R-CHOP (rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone (prednisolone)), then the symptom was improved. In case of caude equine syndrome with M-proteinemia, a possibility of the malignant lymphoma should also be considered.
Full Text of this Article in Japanese PDF (1524K)

(CLINICA NEUROL, 58: 223|228, 2018)
key words: diffuse large B cell lymphoma, neurolymphomatosis, M-proteinemia, cauda equine syndrome

(Received: 4-Aug-17)