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• Vol.57 No.6
• CLINICA NEUROL, 57: 259−273, 2017
• Vol.57 No.6 contents

Review

New development of diagnosis and treatment for Parkinson's disease

Satoshi Orimo, M.D., Ph.D.¹⁾

¹⁾Department of Neurology, Kanto Central Hospital

New methods for the diagnosis and new treatments for Parkinson's disease (PD) were explained. As imaging tools, neuromelanin imaging using brain MRI, meta-iodobenzylguanidine (MIBG) cardiac scintigraphy, dopamine transporter scintigraphy, and transcranial sonography were introduced. Olfactory dysfunction and REM sleep behavior disorders (RBD), which are important non-motor symptoms, and the new Clinical Criteria for PD launched by Movement Disorder Society (MDS) were also described. Investigative new medications and new anti-PD medications, which recently became available in Japan, were introduced. I explained the rationale of early treatment, strategy of initial treatment, the significance of continuous dopaminergic stimulation, strategy of treatment for advanced PD, and deep brain stimulation as a surgical treatment together with promising new treatments including gene therapy and cell transplantation.
Full Text of this Article in Japanese PDF (1094K)

(CLINICA NEUROL, 57: 259−273, 2017)
key words: MIBG cardiac scintigraphy, dopamine transporter scintigraphy, olfactory function, REM sleep behavior disorder, continuous dopaminergic stimulation

(Received: 8-Oct-16)