Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of hemifacial paresis in a patient with Lyme neuroborreliosis treated with antibiotics in whom Borrelia meningitis developed

Hisao Shimizu, M.D.1), Koji Haratani, M.D.2), Masayuki Miyazaki, M.D.1), Yoshiaki Kakehi, M.D.1), Shuhei Nagami, M.D.1), Yuichi Katanami, M.D.3), Hiroki Kawabata, Ph.D.4) and Nobuyuki Takahashi, Ph.D.1)

1)Department of Neurology, Nara City Hospital
2)Department of Medical Oncology, Kinki University Faculty of Medicine
3)Disease Control and Prevention Center (DCC), National Center for Global Health and Medicine
4)Department of Bacteriology 1, National Institute of Infectious Disease

A 38-year-old man visited our hospital because of hemifacial paresis that developed 2 months after being bit by a tick. We diagnosed idiopathic peripheral facial palsy and gave the patient oral prednisolone and valacyclovir. Although the symptoms completely resolved in about 2 weeks, there was a risk of Lyme neuroborreliosis. The patient therefore received doxycycline (100 mg twice daily) and amoxicillin (1,000 mg 3 times daily) for 14 days. Two months later, he had symptoms of meningitis such as headache and fever accompanied by lymphocytic cerebrospinal fluid pleocytosis. Viral meningitis was diagnosed and treated with parenteral acyclovir. The symptoms of meningitis improved. Tests for serum IgG antibodies against borrelia were positive. We gave the patient a diagnosis of Lyme neuroborreliosis. The patient received intravenous ceftriaxone and had no relapse. It is a rare for meningitis to develop in a patient with cranial neuropathy who received doxycycline. Lyme neuroborreliosis is a rare disease in Japan. Care should therefore be exercised in the diagnosis of Lyme neuroborreliosis and evaluation of the response to treatment.
Full Text of this Article in Japanese PDF (386K)

(CLINICA NEUROL, 56: 495|498, 2016)
key words: Lyme neuroborreliosis, hemifacial paresis, meningitis, doxycycline, antibiotics

(Received: 23-Feb-16)