Rinsho Shinkeigaku (Clinical Neurology)

Case Report

Fisher syndrome with delayed facial weakness and taste impairment: a case report

Daisuke Yamamoto, M.D.1), Syuuichirou Suzuki, M.D.1), Bungo Hirose, M.D.2), Minoru Yamada, M.D.3), Masaki Shimizu, M.D.1) and Shun Shimohama, M.D.1)

1)Department of Neurology, Sapporo Medical University School of Medicine
2)Department of Neurology, Sapporo Kousei General Hospital
3)Department of Neurology, Sunagawa City Medical Center

A 55-year-old man was admitted to our hospital because of acute onset of diplopia and gait disturbance. On admission, ophthalmoplegia, ataxia and areflexia were observed. He was diagnosed with Fisher syndrome and given intravenous immunoglobulin therapy from day 6 to day 10 after disease onset. After treatment, ophthalmoplegia and ataxia began to improve. However, he developed taste impairment on day 13 and right hemifacial weakness on day 16 after onset. A blink reflex test revealed right facial nerve impairment. On day 42 after onset, facial weakness and taste impairment remitted, and the blink reflex test result was normalized without additional treatment. Although it has been known that 10% of patients with Fisher syndrome complicated by delayed facial nerve palsy, the mechanism of the facial nerve palsy has not been elucidated. Therefore, this is a significant report to describe delayed facial nerve palsy combined with taste impairment and successive recordings of blink reflex and facial nerve conduction in a patient with Fisher syndrome.
Full Text of this Article in Japanese PDF (740K)

(CLINICA NEUROL, 56: 684|689, 2016)
key words: Fisher syndrome, facial palsy, taste impairment, blink reflex, GQ1b antibody

(Received: 10-May-16)