Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of chronic inflammatory demyelinating polyradiculoneuropathy after treatment with pegylated interferon α-2a in a patient with chronic hepatitis B virus infection

Hiroyuki Naito, M.D.1), Ikuko Takeda, M.D., Ph.D.1), Akiko Segawa, M.D.1), Masataka Tsuge, M.D., Ph.D.2), Hirofumi Maruyama, M.D., Ph.D.1) and Masayasu Matsumoto, M.D., Ph.D.1)

1)Department of Neurology, Hiroshima University Hospital
2)Department of Gastroenterology and Metabolism, Hiroshima University Hospital

We report the case of a 42-year-old man with chronic hepatitis B virus infection who developed weakness and paresthesia in the extremities 2 months after administration of pegylated interferon (Peg-IFN)α-2a. Nerve conduction studies conducted 6 months after onset showed abnormal temporal dispersions in both tibial nerves. We diagnosed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) resulting from treatment with Peg-IFNα-2a. Neurological symptoms were prolonged despite suspension of the treatment. Subsequent treatment with intravenous immunoglobulin improved both clinical symptoms and temporal dispersion. IFNα-induced CIDP is rare, but can reportedly progress even after interruption of IFN-α without immunotherapy. Patients presenting with polyneuropathy after initiation of IFN-α thus require close attention.
Full Text of this Article in Japanese PDF (552K)

(CLINICA NEUROL, 56: 672|677, 2016)
key words: chronic inflammatory demyelinating polyradiculoneuropathy, pegylated interferon α-2a, chronic hepatitis B virus infection, intravenous immunoglobulin

(Received: 16-Mar-16)