Rinsho Shinkeigaku (Clinical Neurology)

Symposium 31

The association of Parkinson's disease pathogenesis with inflammation

Shinji Saiki, M.D. Ph.D.1)

1)Department of Neurology, Juntendo University School of Medicine

Recent research on pathogenesis of neurodegenerative diseases has revealed that neuroinflammation derived from glial activation enhances the progression of devastating diseases including Parkinson's disease (PD). Although whether or not PD-onset is triggered by neuroinflammatory mechanisms remains unclear, various experimental evidences mainly using cellular and mice models have suggested that cytokines like IL-1β, TNFα and IL-6, and secreted α-synuclein from the neurons activate the microglias, resulting in the disease exacerbation. Also, levels of serum/plasma cytokines such as IL-1β, TNFα, IL-2 and ApoA1 have been reported to be significantly elevated in patients with PD compared to the controls. In this summary, I will report the present status of PD pathogenesis associated with neuroinflammation based on the latest reports associated with PD molecular mechanism focusing on the neuroinflammation.
Full Text of this Article in Japanese PDF (489K)

(CLINICA NEUROL, 54: 1125|1127, 2014)
key words: Parkinson's disease, microglia, inflammatory cytokines, biomarker

(Received: 24-May-14)