Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of subacute parkinsonism presenting as bilateral basal ganglia legions by MRI in diabetic uremic syndrome

Yoshiko Nishimura, M.D.1), Koichi Shibata, M.D., Ph.D.1), Takenori Funaki, M.D.1), Hiroyuki Ito, M.D.1), Eiichi Ito, M.D.1) and Kuniaki Otsuka, M.D., Ph.D.1)

1)Tokyo Women's Medical University Medical Center East, Department of Medicine

A 60-year-old male was admitted because he had developed tremulous movement in both upper and lower limbs and gait disturbance over the course of 3 months. He had been on continuous ambulatory peritoneal dialysis almost 1 year earlier due to end-stage diabetic nephropathy. A neurological examination revealed a mild disturbance of his consciousness, asterixis in the upper limbs, bilateral extensor plantar responses and parkinsonism, which were characterized by bradykinesia, akinesia, rigidity, and bilaterally tremors at rest. Cranial magnetic resonance imaging (MRI) revealed swollen bilateral basal ganglia legions, which appeared hyperintense on T2-weighted images. The patient was treated for metabolic acidosis and continued hemodialysis three times a week; however, the parkinsonism remained 1 year later. Follow-up MRI revealed decreased swelling of the basal ganglia, and the pattern of diffusion-weighted images and the apparent diffusion coefficient (ADC) map indicated vasogenic and cytotoxic edema in bilateral globus pallidus. The case was diagnosed as encephalopathy due to diabetic uremic syndrome, initially characterized by Wang et al. (2003). Only 17 cases with parkinsonism have been reported. Diabetic uremic syndrome is characterized by acute or subacute onset consciousness disturbance and movement disorders such as parkinsonism, chorea and the other extrapyramidal signs to various degrees related to bilateral lesions of the basal ganglia.
Full Text of this Article in PDF (3905K)

(CLINICA NEUROL, 53: 217|223, 2013)
key words: basal ganglia, parkinsonism, diabetic uremic syndrome, movement disorders

(Received: 13-Apr-12)