Rinsho Shinkeigaku (Clinical Neurology)

Symposium 17

Therapeutic responsiveness in chronic inflammatory demyelinating polyradiculoneuropathy

Masahiro Iijima, M.D.

Department of Neurology, Nagoya University

CIDP is autoimmune-associated peripheral neuropathy characterized by motor and sensory disturbances in each limb. While various phenotypes have been reported in CIDP, the essential pathogenesis is not elucidated yet. Clinicopathological study indicated axonal dysfunction (muscle atrophy and decreased compound muscular action potentials) is one of the most important factors in IVIg Non-responders. Furthermore, single nucleotide polymorphism (SNP) haplotype/diplotype analysis within a linkage disequilibrium block indicates transient axonal glycoprotein 1 (TAG-1), which controls proper distribution of potassium channels in juxtaparanode, is an important factor for IVIg responsiveness. Gene expression analysis of biopsied nerves supported the hypothesis that CIDP pathogenesis is involved in humoral and cellular immune system. With respect to IVIg responsiveness, expression profiles indicate whole CIDP patients need conventional immune-modulating therapies in somewhat, while we should re-consider how to use them. From aspects of gene expression results, Non-responders need not only conventional immune-modulating therapies but also other original modalities which could intervene the pathogenesis except Schwann/inflammatory cells while Responders with IVIg dependence should need stronger and longer immune-suppression.
Full Text of this Article in Japanese PDF (188K)

(CLINICA NEUROL, 51: 1012|1014, 2011)
key words: chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), Intravenous immunoglobulin (IVIg), single nucleotide polymorphism (SNP), gene expression, therapeutic responsiveness

(Received: 19-May-11)