Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

A case of status epilepticus with a possible therapeutic effect by dantrolene sodium

Atsunori Hiasa, M.D.1), Ryogen Sasaki, M.D.2), Toshiaki Takeuchi, M.D.1) and Hidekazu Tomimoto, M.D.2)

1)Department of the Internal Medicine, Tohyama Hospital
2)Department of Neurology, Mie University Graduate School of Medicine

We report a 62-year-old man who have taken major tranquilizer for schizophrenia for the past 24 years. He had sudden generalized tonic-clonic seizure and consciousness loss on April 2010. He was administered diazepam, phenytoin, phenobarbital intravenously and drip-infused with midazolam continuously, but the seizure persisted. For a possible comorbidity of neuroleptic malignant syndrome, we administered dantrolene sodium intravenously and bromocriptine through a nasal gastric tube. The refractory status epilepticus disappeared immediately after the administration. Status epilepticus remitted 2 days later but again disappeared with repeated injection of dantrolene. These results suggested that intravenous administration of dantrolene may have alleviated the refractory symptoms of status epilepticus.
Full Text of this Article in Japanese PDF (446K)

(CLINICA NEUROL, 51: 777|780, 2011)
key words: convulsive status epilepticus, antiepileptic drug, dantrolene, schizophrenia, neuroleptic malignant syndrome

(Received: 21-Apr-11)