Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

A case of limbic encephalitis associated with leucine-rich glioma-inactivated 1 antibody

Hiroshi Yaguchi, M.D.1), Toshiaki Hirai, M.D.1), Akira Kurita, M.D.1) and Soichiro Mochio, M.D.2)

1)Department of Neurology, The Jikei University Kashiwa Hospital
2)Department of Neurology, The Jikei University School of Medicine

We report a 55-year-old woman with limbic encephalitis associated with leucine-rich glioma-inactivated 1 (LGI1) antibody. She first developed a generalized seizure, following by consciousness loss. Although anticonvulant was initially effective, she began to present frequently with seizure and memory impairment. After eleven months from onset, she was admitted due to generalized seizure. Neurological examination after recovering from the treatment with anesthetic agent demonstrated disorientation and memory impairment. Cerebrospinal fluid analysis was unremarkable. MR brain FLAIR imaging demonstrated high intensity lesions in the medial parts of the both temporal lobes, suggesting limbic encephalitis. There were no signs of malignant tumor detected on systemic examination. LGI1 antibody was positive in the cerebrospinal fluid and we finally diagnosed this patient as having limbic encephalitis associated with LGI1 antibody. She demonstrated a good response to steroid therapy and was discharged after one month.
Full Text of this Article in Japanese PDF (274K)

(CLINICA NEUROL, 51: 774|776, 2011)
key words: limbic encephalitis, autoimmune encephalitis, Anti-voltage-gated potassium channel antibody, Anti-leucinerich glioma-inactivated 1 antibody

(Received: 1-Apr-11)