Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

Subacute sensory neuronopathy associated with squamous cell carcinoma of the lung: A case report

Yuichi Noto, M.D.1), Kensuke Shiga, M.D.1), Jun Fujinami, M.D.1), Toshiki Mizuno, M.D.1), Masanori Nakagawa, M.D.1) and Keiko Tanaka, M.D.2)

1)Department of Neurology, Kyoto Prefectural University of Medicine
2)Department of Neurology, Kanazawa Medical University

We report a 59-year-old man who developed dysesthesia in all extremities with severe loss of deep sensation over three months. A radiating radicular pain was also noted in the extremities. The nerve conduction study barely elicited sensory nerve action potentials both in the median and in the sural nerve. An extensive search for anti-neuronal antibodies including anti-Hu and anti-CV2 antibody was negetive. The biopsy specimen of an enlarged tracheobronchial lymph node revealed squamous cell carcinoma. The subsequent chemotherapy and radiation therapy for the neoplasm improved the radicular pain and the deep sensation to a moderate extent, leading to the diagnosis of paraneoplastic subacute sensory neuropathy (SSN). In general, cases with paraneoplastic SSN are associated mostly with small cell lung cancer, and quite rarely with squamous cell lung cancer. The early detection and the treatment of the primary tumor are crucial in a patient with subacute progression of sensory-dominant neuropathy.
Full Text of this Article in Japanese PDF (382K)

(CLINICA NEUROL, 49: 497|500, 2009)
key words: paraneoplastic subacute sensory neuropathy, squamous cell lung cancer

(Received: 7-Apr-09)