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• Vol.48 No.2
• CLINICA NEUROL, 48: 139−142, 2008
• Vol.48 No.2 contents

Brief Clinical Note

Impaired recognition of emotion improved by L-DOPA in a patient with amygdala damage

Tatsuya Sato, M.D.¹⁾²⁾, Nobuyoshi Takahashi, M.D.¹⁾ and Mitsuru Kawamura, M.D.¹⁾

¹⁾Department of Neurology, Showa University School of Medicine
²⁾Department of Neurology, Omuta Tenryo Hospital

We examined the effect of levodopa (L-DOPA) in a patient with a lesion of the amygdala and impaired recognition of emotion. Before L-DOPA, recognition of fear and disgust was significantly impaired compared to recognition scores in controls. After receiving L-DOPA, the patient showed normal recognition of fear and disgust. After the drug wore off, recognition declined to her initial unmedicated performance. We hypothesized that L-DOPA may have activated dopaminergic systems involved in recognition of emotion such as the medial prefrontal cortex and anterior cingulate cortex, compensating for the amygdala dysfunction. Alternatively, L-DOPA may have activated intact portions of the amygdala.
Full Text of this Article in Japanese PDF (282K) Members Only

(CLINICA NEUROL, 48: 139−142, 2008)
key words: amygdala, recognition of emotion, L-DOPA, herpes simplex encephalitis

(Received: 24-Feb-07)