Rinsho Shinkeigaku (Clinical Neurology)

The 49th Annual Meeting of the Japanese Society of Neurology

Neuropathological perspective on single slide

Asao Hirano, M.D.

Division of Neuropathology, Montefiore Medical Center

During over 50 years of my career in Neuropathology at Montefiore Medical Center in New York, I have come across certain interesting neuropathological findings. In this communication, some photographs showing macroscopic, microscopic and electron microscopic significant findings are selected to illustrate the usefulness, not only for the diagnosis but also for the understanding of the nervous system. The 11 topics presented in this paper are: (1) alteration of dura mater associated with advanced aging; (2) orderly arrangement of tumor cells in leptomeningeal carcinomatosis; (3) horizontal section of brain with border zone infarct; (4) neurofibrillary tangle formation in the nucleus basalis Meynert ipsilateral to a massive cerebral infarct; (5) extracellular spread of hematogenous edema fluid in the white matter; (6) unrolled myelin sheath; (7) unattached presynaptic terminals in cerebellar neuroblastoma; (8) unattached post synaptic terminals in agranular cerebellar degeneration; (9) neurofibrillary tangles and Lewy bodes in a single neuron; (10) Cu/Zu superoxide dismutase positive Lewy body-like hyaline inclusions in anterior horn cells in familial motor neuron disease; (11) Hirano body. Analysis of these findings are presented for an educational purpose.
Full Text of this Article in Japanese PDF (333K)

(CLINICA NEUROL, 48: 804|808, 2008)
key words: brain edema, myelin, synapse, Lewy body-like inclusion, Hirano body

(Received: 17-May-08)