臨床神経学

<シンポジウム(1)―6―3>認知症疫学研究が提供するエビデンス

認知症の危険因子と予防療法

里 直行

大阪大学大学院医学系研究科臨床遺伝子治療学〔〒565―0871 吹田市山田丘2―2〕
同 老年・腎臓内科学

Growing evidence supports that diabetes mellitus (DM) is one of the non-genetic risk factors for Alzheimer's disease (AD). However, the mechanisms by which DM increases the risk of AD have not been fully understood. Epidemiological studies suggested that DM modifies AD pathology. The studies using AD animal models with DM also indicated that these two types of diseases interacted pathologically with each other. Elucidation of the mechanism of the pathological interaction between AD and DM could open the door for generation and development of novel therapeutic strategies for AD, especially in the elderly.
Full Text of this Article in Japanese PDF (362K)

(臨床神経, 52:968−970, 2012)
key words:アルツハイマー病,糖尿病,ベータアミロイド,タウ,インスリン・シグナル

(受付日:2012年5月23日)