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  会員専用

• ホーム
• 52巻11号
• 臨床神経, 52：939−941, 2012
• 52巻11号目次

＜シンポジウム（1）―4―3＞ALSに対する再生医療の開発

成体脳に内在する神経前駆細胞をもちいた神経再生

澤本　和延

名古屋市立大学医学研究科再生医学分野〔〒467―8601 名古屋市瑞穂区瑞穂町字川澄1番地〕

Currently, there is no effective treatment for the neuronal loss caused by neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) or ischemic stroke. However, recent studies have shown that endogenous neural progenitor cells continuously generate new neurons in the subventricular zone (SVZ) of the adult mammalian brain. Some of these new neurons migrate to the injured site and differentiate into mature neurons. Such new neurons may be able to replace degenerated neurons and improve or repair neurological deficits. To establish a neuroregenerative therapy using this endogenous system, endogenous regulatory mechanisms must be understood. Here, we review current knowledge on the generation of new neurons in the adult brain and discuss their potential for use in replacing neurons lost to neurodegenerative diseases, including ALS, and to ischemic stroke.
Full Text of this Article in Japanese PDF (298K)

(臨床神経, 52：939−941, 2012)
key words：神経前駆細胞，脳室下帯，神経再生，神経幹細胞

（受付日：2012年5月23日）