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  会員専用

• ホーム
• 52巻11号
• 臨床神経, 52：1329−1331, 2012
• 52巻11号目次

＜シンポジウム（3）―11―3＞神経変性疾患の病態解明・その病態とバイオマーカーの開発を目指して

Non-Autonomous Cell Deathは神経変性疾患の共通機構か？

山中　宏二

理化学研究所脳科学総合研究センター・運動ニューロン変性研究チーム〔〒351―0198 埼玉県和光市広沢2―1〕

Although glial activation and proliferation is widely seen in the lesion of neurodegenerative diseases, the active roles of glial cells in the disease process have recently been elucidated. In this symposium, the research progress toward establishing the concept "non-cell autonomous" neurodegeneration is reviewed. While the glial cells are important component of "non-cell autonomous" neurodegeneration, the recent research suggests immune cells and related inflammation are also involved in pathomechanisms. Accumulating knowledge of "non-cell autonomous" neurodegeneration is now applied to many neurodegenerative diseases including ALS, Alzheimer's and Parkinson's diseases, and polyglutamine diseases, and should be carefully applied to further understanding of the sporadic neurodegenerative diseases and development of therapy targeted for non-neuronal cells.
Full Text of this Article in Japanese PDF (189K)

(臨床神経, 52：1329−1331, 2012)
key words：神経変性疾患，グリア，炎症

（受付日：2012年5月25日）