臨床神経学

<シンポジウム34―4>脳梗塞:Tissue clockとReperfusion

Tissue Clock Measurement DeviceとしてのMRS

五十嵐 博中

新潟大学脳研究所統合脳機能研究センター〔〒951―8585 新潟県新潟市旭町通1―757〕

Proton magnetic resonance spectroscopy (1H-MRS) non-invasively provides in vivo biochemical information on tissue metabolites. In acute stage of cerebral ischemia, N-acetyl aspartate (NAA), one of 1H-MRS observable metabolite, declines gradually reflecting energy impairment due to oxygen depletion. In our study, decline of NAA in ischemic core linearly correlated with the time from the onset of ischemia. Therefore NAA can be utilized to time clock biomarker for the acute stage cerebral ischemia.
Full Text of this Article in Japanese PDF (342K)

(臨床神経, 51:1178−1181, 2011)
key words:脳虚血,磁気共鳴スペクトロスコピー

(受付日:2011年5月20日)