Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of primary central nervous system lymphoma of the sellar region presented with panhypopituitarism

Ayaka Seki, M.D.1), Fumiaki Henmi, M.D.1), Shinji Ito, M.D.2), Hironori Uruga, M.D., Ph.D.2), Kei Arisawa, M.D.3) and Yoshikazu Uesaka, M.D.1)

1) Department of Neurology, Toranomon Hospital
2) Department of Diagnostic Pathology, Toranomon Hospital
3) Department of Neurosurgery, Toranomon Hospital

The patient is a 41-year-old woman. She presented with vomiting and lightheadedness, and blood tests showed a generalized decrease in pituitary hormones and hyperprolactinemia. A head MRI showed increased signal intensity lesions on FLAIR image in the pituitary stalk, corpus callosum, periventricular area of the fourth ventricle, and superior cerebellar peduncle. The lesions were homogeneously enhanced, and a brain biopsy confirmed the diagnosis of primary diffuse large B-cell lymphoma of the central nervous system, and chemotherapy was started. Although the suprasellar region is a rare site for primary central nervous system lymphoma (PCNSL), it should be diagnosed early by biopsy.
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(CLINICA NEUROL, 64: 356−360, 2024)
key words: primary central nervous system lymphoma, hypopituitarism, pituitary stalk, hypothalamus

(Received: 27-Oct-23)