Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of caseous calcification of mitral annulus resulting in multiple cerebral infarctions

Yoshifumi Ogasawara, M.D.1), Kagari Mano, M.D., Ph.D.1)2), Fumiaki Henmi, M.D.1), Yoshikazu Uesaka, M.D.1) and Yutaka Takazawa, M.D.3)

1) Department of Neurology, Toranomon Hospital
2) Department of Neurology, Yokohama Rosai Hospital
3) Department of Pathology, Toranomon Hospital

The patient is a 73-year-old woman. She presented with dysarthria, and a head MRI revealed multiple acute cerebral infarctions in the bilateral cerebral hemisphere and cerebellar hemisphere. Transesophageal echocardiography after admission revealed a 16 mm large mobile calcification of the mitral annulus (caseous calcification of the mitral annulus; CCMA) on the posterior apex of the mitral valve annulus. Since the CCMA had a high risk of relapse, and a new infarction was detected on the 8th day, resection of the mass and mitral valve replacement surgery were performed. CCMA is a subtype of mitral annular calcification (MAC). When calcification progresses from the MAC state to form a mass, it is called a calcified amorphous tumor; CAT. Reports of embolic cerebral infarction caused by CAT are rare, but this is a rare report of an embolic cerebral infarction from CCMA presenting as CAT.
Full Text of this Article in Japanese PDF (2021K)

(CLINICA NEUROL, 63: 97|100, 2023)
key words: multiple cerebral infarctions, caseous calcification of the mitral annulus, mitral annular calcification, calcified amorphous tumor

(Received: 1-Nov-22)