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• Vol.62 No.5
• CLINICA NEUROL, 62: 363−368, 2022
• Vol.62 No.5 contents

Case Report

A case of anti-SRP antibody-positive immune-mediated necrotizing myopathy triggered by human parvovirus B19 infection

Iku Suzuki, M.D.¹⁾, Ryohei Nakao, M.D.¹⁾, Yuki Unai, M.D.¹⁾ and Yoshimichi Miyazaki, M.D., Ph.D.¹⁾

¹⁾ Department of Neurology, Hyogo Prefectural Awaji Medical Center

We have reported a case of a 44-year-old woman with anti-signal recognition particle (SRP) antibody-positive immune-mediated necrotizing myopathy triggered by human parvovirus B19 (PVB19) infection. She was admitted to the hospital because of lower leg edema and muscle weakness after erythema infectiosum. Magnetic resonance imaging of the lower extremities revealed high signals in the proximal muscles and subcutaneous edema on STIR. Muscle biopsy showed myofiber regenerative changes and variation in fiber size. A myositis-specific autoantibody profile indicated a positive result for anti-SRP antibodies. We diagnosed the patient with immune-mediated necrotizing myopathy (IMNM). Muscle strength and subcutaneous edema improved gradually in 3 months following immunotherapy. This is the first case report of an IMNM associated with PVB19 infection.
Full Text of this Article in Japanese PDF (2205K)

(CLINICA NEUROL, 62: 363−368, 2022)
key words: immune-mediated necrotizing myopathy, anti-signal recognition particle antibodies, human parvovirus B19, subcutaneous edema

(Received: 11-Aug-21)