Rinsho Shinkeigaku (Clinical Neurology)

Case Report

An 11 year old woman with myelin-oligodendrocyte glycoprotein antibody showing various phenotypes of central nervous system disorders in one year

Namiko Oshibe, M.D.1), Yukio Takeshita, M.D., Ph.D.1), Shiori Takahashi, M.D., Ph.D.1), Mariko Oishi, M.D., Ph.D.1), Yasuteru Sano, M.D., Ph.D.1) and Takashi Kanda, M.D., Ph.D.1)

1) Department of Clinical Neuroscience and Neurology, Yamaguchi University Graduate School of Medicine

An 11-year-old woman with myelin-oligodendrocyte glycoprotein (MOG) antibody developed cortical encephalitis twice, followed by acute disseminated encephalomyelitis (ADEM) and optic neuritis in one year. Although optic neuritis was refractory after corticosteroid therapy, plasma exchange was effective and complete remission was achieved. We considered that episodes of cortical encephalitis, ADEM and optic neuritis occurred in the present patient can be included in MOG IgG-associated disorders. Also, we recommend plasma exchange for refractory MOG IgG-associated optic neuritis, even in pediatric patient.
Full Text of this Article in Japanese PDF (2114K)

(CLINICA NEUROL, 62: 211−216, 2022)
key words: MOG antibody, cortical encephalitis, optic neuritis, acute disseminated encephalomyelitis (ADEM), plasma exchange

(Received: 12-Aug-21)