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• Vol.61 No.8
• CLINICA NEUROL, 61: 543−546, 2021
• Vol.61 No.8 contents

Case Report

Anti-striational antibodies detected in a patient with late-onset myasthenia gravis suffering from severe bradycardia: a case report

Rina Fujita, M.D.¹⁾, Shun Matoba, M.D.¹⁾, Hirokazu Morihata, M.D., Ph.D.¹⁾ and Manabu Inoue, M.D., Ph.D.¹⁾

¹⁾ Department of Neurology, Osaka City General Hospital

We report herein the case of a 79-year-old woman who experienced difficulties in swallowing, dysarthria, dropped head, and muscle weakness associated with diurnal and day-to-day variation. We made a diagnosis of generalized myasthenia gravis (MG) with anti-acetylcholine receptor antibodies. Contrast-enhanced computed tomography showed no sign of thymoma. As the MG worsened, the patient presented with severe bradycardia. Chest compressions were performed on days 6 and 7 after admission and she underwent implantation of a temporary pacemaker. The arrhythmia resolved after strong immunosuppressive treatment, and anti-striational antibodies, including anti-muscular voltagegated potassium channel-complex (Kv1.4) antibody and anti-titin antibody, were subsequently detected. This case implies the possible involvement of anti-striational antibodies in bradycardia.
Full Text of this Article in Japanese PDF (853K) 　　　　 Full Text of this Article in English HTML

(CLINICA NEUROL, 61: 543−546, 2021)
key words: myasthenia gravis, thymoma, anti-striational antibodies, arrhythmia

(Received: 25-Jan-21)