Rinsho Shinkeigaku (Clinical Neurology)

Case Report

Paraneoplastic sensorimotor neuropathy with anti-Hu antibody associated with gallbladder carcinoma

Shizuka Harada, M.D.1), Yuichiro Inatomi, M.D.1), Makoto Nakajima, M.D.2) and Toshiro Yonehara, M.D.1)

1) Department of Neurology, Saiseikai Kumamoto Hospital, Kumamoto
2) Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto

A 78-year-old woman experienced gait disturbance. She became unable to walk within a month. On admission, her cranial nerves were normal. She had motor weakness in the arms and legs, dysesthesia of the peripheral extremities, impaired deep sensation in the legs, and hyporeflexia in the arms and legs. She was initially diagnosed with Guillain-Barré syndrome; therefore, she was treated with intravenous immunoglobulin therapy and steroid mini-pulse therapy, however improvements of her neurological deficits were minimal. Anti-Hu antibody was positive in serum and gallbladder carcinoma was detected. She was treated with chemotherapy but neurological symptoms worsened progressively. Gallbladder carcinoma can rarely cause anti-Hu associated paraneoplastic sensorimotor neuropathy.
Full Text of this Article in Japanese PDF (1355K)      Full Text of this Article in English HTML

(CLINICA NEUROL, 61: 471−476, 2021)
key words: paraneoplastic neurological syndrome, sensorimotor neuropathy, gallbladder carcinoma, anti-Hu antibody

(Received: 13-Jan-21)