Rinsho Shinkeigaku (Clinical Neurology)

Case Report

Varicella-zoster meningoencephalitis and vasculitis after treatment with amenamevir to herpes zoster in the trigeminal nerve area

Yoko Taniguchi, M.D.1), Yuya Kano, M.D.1), Taro Kitamura, M.D.1), Toshiyasu Miura, M.D., Ph.D.1) and Kentaro Yamada, M.D., Ph.D.1)

1) Department of Neurology, Nagoya City East Medical Center

A 78-year-old woman was diagnosed with herpes zoster in the first branch of the trigeminal nerve and was treated with amenamevir. Subsequently, she was hospitalized for postherpetic neuralgia. Fever and unconsciousness were observed, and a diagnosis of varicella-zoster virus meningoencephalitis and vasculitis was made. In addition to the antithrombotic therapy, she was treated with intravenous acyclovir and steroid pulse therapy; however, her unconsciousness persisted. Amenamevir was not transferrable to the spinal fluid and resulted in an incomplete treatment of herpes zoster in the cerebral nerve region, suggesting that this case may be related to the severe course of the disease.
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(CLINICA NEUROL, 61: 239−242, 2021)
key words: varicella-zoster virus vasculitis, varicella-zoster virus meningoencephalitis, amenamevir

(Received: 14-Aug-20)