Rinsho Shinkeigaku (Clinical Neurology)

Case Report

Myelomatous meningitis: a case report

Yuriko Aratake, M.D.1j, Ryosuke Takaya, M.D.2j and Katsuro Shindo, M.D., Ph.D.1j

1) Department of Neurology, Kurashiki Central Hospital
2) Department of Hematology, Kurashiki Central Hospital

We present the case of a 67-year-old woman with meningeal carcinomatosis who was treated with chemotherapy for refractory multiple myeloma, and was in remission. She was admitted to our hospital because of tonic seizures and disturbance of consciousness. Monoclonal CD 138-positive plasma cells were detected in her cerebrospinal fluid. Cranial MRI showed gadolinium enhancement of diffuse meninges and cranial nerves. We diagnosed the patient with systemic epilepsy due to meningeal carcinomatosis and administered antiepileptic drugs and intrathecal chemotherapy; however, she showed little improvement, and she passed away on hospital day 74 because of disease progression. Multiple myeloma is known to be associated with neurological symptoms such as peripheral neuropathy, myelopathy, and radiculopathy; however, central nervous system involvement in multiple myeloma is uncommon. We should consider central nervous system involvement in multiple myeloma, such as meningeal carcinomatosis, given the importance of early detection and therapeutic intervention.
Full Text of this Article in Japanese PDF (1208K)

(CLINICA NEUROL, 61: 739|742, 2021)
key words: multiple myeloma, meningeal carcinomatosis, systemic epilepsy

(Received: 3-Mar-21)