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• Vol.60 No.2
• CLINICA NEUROL, 60: 157−161, 2020
• Vol.60 No.2 contents

Case Report

Two adult patients with acute necrotizing encephalopathy following influenza virus infection

Kentaro Iizuka, M.D.¹⁾, Keisuke Suzuki, M.D., Ph.D.¹⁾, Tomohiko Shiina, M.D., Ph.D.¹⁾, Toshiki Nakamura, M.D., Ph.D.²⁾, Kei Funakoshi, M.D., Ph.D.¹⁾ and Koichi Hirata, M.D., Ph.D.¹⁾

¹⁾Department of Neurology, Dokkyo Medical University
²⁾Department of Neurology, Rehabilitation Amakusa Hospital

Influenza encephalopathy is characterized by high fever, disturbance of consciousness following influenza virus infection. We encountered 2 adult patients with influenza-associated acute necrotizing encephalopathy (Case 1, a 70-yearold woman with diabetes; Case 2, a 49-year-old woman with multiple myeloma), showing hemorrhagic lesions in the bilateral thalamus. Case 1 presented with fever and disturbance of consciousness followed by status epilepticus, and Case 2 developed fever and drowsiness as initial manifestation. Influenza type A was positive in Case 1 and influenza type B was positive in Case 2. In the acute phase, 2 patients required respiratory ventilation and were treated with antiinfluenza drug, steroid and immunoglobulin. Cognitive impairment remained in the both patients in the chronic phase. When acute necrotizing encephalopathy is suspected, intensive treatment should be started as early as possible to improve clinical outcome of patients.
Full Text of this Article in Japanese PDF (1216K)

(CLINICA NEUROL, 60: 157−161, 2020)
key words: acute necrotizing encephalopathy, influenza virus infection, adult patients

(Received: 9-Oct-19)