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• Vol.60 No.12
• CLINICA NEUROL, 60: 852−856, 2020
• Vol.60 No.12 contents

Case Report

A case of anti-SRY-Related HMG-Box Gene 1 (SOX1) antibody-positive chorea

Takuma Yamagishi, M.D.¹⁾, Kana Inoue, M.D.¹⁾, Haruka Ouchi, M.D.¹⁾, Ken Shibano, M.D., Ph.D.¹⁾ and Kenju Hara, M.D., Ph.D.¹⁾

¹⁾ Department of Neurology, Akita Red Cross Hospital

A 77-year-old man with a history of lung cancer at the age of 71 developed involuntary right leg movement for a month. Neurological examination revealed a right-sided hemi-chorea. Autoimmune disease was suspected owing to the presence of oligoclonal bands and the elevated IgG-index in the cerebrospinal fluid. We detected anti-SRY-Related HMGBox Gene 1 (SOX1) antibodies, known to be serological markers of Lambert-Eaton syndrome with small cell lung cancer, but not tumors. The results of tests for antiphospholipid, anti-LGI1, and anti-CASPR2 antibodies associated with nonparaneoplastic autoimmune chorea were all negative. This is the first suggestive case of autoimmune chorea in which anti-SOX1 antibodies were detected.
Full Text of this Article in Japanese PDF (1035K)

(CLINICA NEUROL, 60: 852−856, 2020)
key words: anti-SOX1 antibody, chorea, paraneoplastic neurological syndrome, lung cancer, autoimmune

(Received: 27-Mar-20)