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• Vol.59 No.10
• CLINICA NEUROL, 59: 652−658, 2019
• Vol.59 No.10 contents

Case Report

Guillain-Barré syndrome with refractory optic neuropathy

Yosuke Takeuchi, M.D.¹⁾²⁾, Yuichiro Inatomi, M.D.¹⁾, Makoto Nakajima, M.D.³⁾ and Toshiro Yonehara, M.D.¹⁾

¹⁾Department of Neurology, Saiseikai Kumamoto Hospital
²⁾Department of Neurology, National Hospital Organization Kumamotominami National Hospital
³⁾Department of Neurology, Graduate School of Medical Sciences, Kumamoto University

A 60-year-old woman with a 3-day history of ataxic gait, blurred vision, and upper extremity paresthesia was admitted to our hospital. She presented with severe visual disturbances (finger counting), ophthalmoplegia, neck weakness, and sensory ataxia. Serum anti-GQ1b antibody, anti-GM3 antibody, and anti-GD3 antibody were strongly positive, which might contribute to the pathogenesis. Since we suspected Guillain-Barré syndrome (GBS), intravenous immunoglobulin therapy (IVIg) and high-dose steroid therapy were administered; however, improvements in her visual acuity were minimal. Additional IVIg and high-dose steroid therapy resulted in limited visual acuity improvements. Therapeutic strategies for patients with GBS and refractory optic neuropathy remain controversial.
Full Text of this Article in Japanese PDF (1539K)

(CLINICA NEUROL, 59: 652−658, 2019)
key words: Guillain-Barré syndrome, optic neuropathy, anti-GQ1b antibody, intravenous immunoglobulin therapy

(Received: 5-Jun-19)