Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of painful seizure accompanying ictal paresis and homonymous hemianopia due to post-stroke epilepsy

Kanta Tanaka, M.D.1)2), Shuji Hashimoto, M.D., Ph.D.3), Yuzuru Harada4), Takashi Kageyama, M.D., Ph.D.1) and Toshihiko Suenaga, M.D., Ph.D.1)

1)Department of Neurology, Tenri Hospital
2)Stroke Center, Tenri Hospital
3)Shirakawa Branch, Tenri Hospital
4)Department of Clinical Pathology, Tenri Hospital

A 69-year-old female with an old infarct of the left parietotemporal lobe was admitted for the evaluation of suspected painful seizures accompanying ictal paresis. The painful seizure and ictal paresis involved her right extremities without convulsions, although intermittent tremulous movements were noted on the right upper extremity. She also showed right hemianopia during the seizure. Ictal scalp EEG demonstrated lateralized rhythmic sharply contoured delta activity intermingled with a large amount of spikes, sharp waves, and fast activity mainly on the posterior half of the left hemisphere. Ictal MRI showed restricted diffusion in the postcentral gyrus and dilatation of distal branches of the left middle cerebral artery (MCA). 99mTc-ECD SPECT revealed hyperperfusion on the left parietal cortex. Treatment with antiepileptic drugs successfully prevented seizure recurrence, then she was discharged home. On the follow-up SPECT after 1 month, the abnormal hyperperfusion disappeared. MRI demonstrated resolution of the restricted diffusion and the MCA dilatation. Taken together with the EEG abnormality and the transient abnormalities in SPECT and MRI, we concluded that her seizures were epileptic and that her painful seizures likely arise from the left primary somatosensory cortex. The mechanism of ictal paresis would be attributed to some disturbed functional architecture in the left primary motor cortex leading to loss of normal motor function through epileptic interference by ictal discharges. The same mechanism in the visual cortex could be assumed for her ictal hemianopia. Painful seizure and ictal paresis each is rarely encountered, even more so the combination thereof. These ictal manifestations might be difficult to differentiate from transient ischemic attack or postictal paresis, and thus EEG is essential to diagnose this treatable condition.
Full Text of this Article in Japanese PDF (1116K)

(CLINICA NEUROL, 58: 492|498, 2018)
key words: epileptic painful seizure, ictal paresis, ictal hemianopia, epileptic negative manifestation, lateralized rhythmic delta activity (LRDA)

(Received: 10-Mar-18)