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• Vol.57 No.5
• CLINICA NEUROL, 57: 220−224, 2017
• Vol.57 No.5 contents

Case Report

A case of chronic sarcoid myopathy with Basedow's disease and Sjogren's syndrome:A case series of sarcoid myopathy

Takashi Isobe, M.D.¹⁾⁵⁾, Madoka Mori-Yoshimura, M.D., Ph.D.¹⁾, Yasushi Oya, M.D.¹⁾, Yuko Saito, M.D., Ph.D.²⁾, Miho Murata, M.D., Ph.D.¹⁾, Ichizo Nishino, M.D., Ph.D.³⁾⁴⁾ and Yuji Takahashi, M.D., Ph.D.¹⁾

¹⁾Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
²⁾Department of Laboratory Medicine, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
³⁾Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
⁴⁾Department of Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan
⁵⁾Department of Neurology, Aizawa Hospital, Nagano, Japan

We report a 62-year-old woman with a history of Basedow's disease and Sjogren's syndrome who presented with slowly progressive limb muscle weakness over the course of ten years. On physical examination, she had dry eye and mouth, but was otherwise normal. Neurological examination revealed symmetrical proximal dominant muscle weakness. Polymyositis was suspected at initial diagnosis due to her clinical course, physical examination, and autoimmune disease. However, the final diagnosis based on a muscle biopsy was the chronic myopathic type of sarcoid myopathy. Among 25 definite sarcoid myopathy cases in the National Center of Neurology and Psychiatry muscle repository from 2010 to 2015, 6/25 had autoimmune diseases. All 6 patients were female and had the chronic myopathic type of sarcoid myopathy. The number of patients with Sjogren's syndrome, thyroid disease, autoimmune hepatitis, and idiopathic thrombocytopenia were 4, 1, 1, and 1, respectively. Only the present case had both thyroid disease and Sjogren's syndrome. In conclusion, the chronic myopathic type of sarcoid myopathy is one possibility to consider in patients who present with progressive myopathy together with autoimmune diseases.
Full Text of this Article in Japanese PDF (704K)

(CLINICA NEUROL, 57: 220−224, 2017)
key words: sarcoid myopathy, Basedow's disease, Sjogren's syndrome, autoimmune diseases, chronic myopathic type

(Received: 14-Feb-17)