Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

A case of pediatric multiple sclerosis presenting with a tumefactive demyelinating lesion

Hisakazu Majima, M.D.1)2), Tsuyoshi Ito, M.D., Ph.D.1) and Norihisa Koyama, M.D., Ph.D.1)

1)Department of Pediatrics, Toyohashi Municipal Hospital
2)Present address: Department of Pediatric Nephrology, Aichi Children's Health and Medical Center

Pediatric multiple sclerosis accompanied by a tumefactive demyelinating lesion (TDL) is extremely rare. Because it is very difficult to distinguish TDLs from neoplasms, invasive brain biopsies are required for a definitive diagnosis. MR spectroscopy (MRS) without brain biopsy was recently shown diagnostic in some patients with TDLs, based on the elevation of glutamate/glutamine peaks. This report describes the clinical course of a 9-year-old girl with multiple sclerosis following a TDL and discusses the usefulness of MRS and brain biopsies to diagnose TDLs.
Full Text of this Article in Japanese PDF (525K)

(CLINICA NEUROL, 57: 88|91, 2017)
key words: pediatric multiple sclerosis, brain biopsy, open ring enhancement, tumefactive demyelinating lesion, MR spectroscopy

(Received: 22-Jun-16)