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• Vol.57 No.2
• CLINICA NEUROL, 57: 63−70, 2017
• Vol.57 No.2 contents

Review

Diagnosis, disease notification, and management of rapid eye movement (REM) sleep behavior disorder

Takayoshi Shimohata, M.D., Ph.D.¹⁾, Yuichi Inoue, M.D., Ph.D.²⁾ and Koichi Hirata, M.D., Ph.D.³⁾

¹⁾Department of Neurology, Brain Research Institute, Niigata University
²⁾Department of Somnology, Tokyo Medical University, Yoyogi Sleep Disorder Center
³⁾Department of Neurology, Dokkyo Medical University

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment behavior during REM sleep. It has been demonstrated that patients with idiopathic RBD are at a significantly increased risk of developing one of the α-synucleinopathies later in life, and this is called "phenoconversion". Although some physicians argue against disclosing information that could cause patients psychological stress, the patients also have a "right to know" about their own disease. Therefore, determining when and how to disclose this information, in addition to appropriate follow-up, is important. Clonazepam is the first choice of treatment for RBD associated with α-synucleinopathies. Since RBD is one of the premotor symptoms of α-synucleinopathies, and enables its early diagnosis, a combination of RBD and other examinations may contribute to the realization of a disease-modifying therapy. It is hoped that the early establishment of biomarkers could help predict the phenoconversion from RBD to α-synucleinopathies.
Full Text of this Article in Japanese PDF (668K)

(CLINICA NEUROL, 57: 63−70, 2017)
key words: REM sleep behavior disorder, α-synucleinopathy, non-motor symptom, premotor symptom, disease-modifying therapy

(Received: 14-Sep-16)