Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of rheumatoid meningitis presented with generalized seizure in whom MRI images were helpful for the diagnosis

Kazuya Yamashita, M.D.1), Yasukazu Terasaki, M.D., Ph.D.1), Manabu Sakaguchi, M.D., Ph.D.1), Yuji Nakatsuji, M.D., Ph.D.1), Kazuyuki Yoshizaki, M.D., Ph.D.2) and Hideki Mochizuki, M.D., Ph.D.1)

1)Department of Neurology, Osaka University Graduate School of Medicine
2)Department of Respiratory, Immunology and Allergy, Osaka University Graduate School of Medicine

We report a 65-years-old woman with rheumatoid meningitis presented with a generalized seizure. She has a 18-year history of rheumatoid arthritis, which has been successfully treated. She developed a generalized seizure. She was diagnosed as having subarachnoid hemorrhage, because the brain magnetic resonance imaging (MRI) showed increased fluid attenuated inversion recovery (FLAIR) signals in her left frontoparietal subarachnoid space. After one month of clinical stabilization, she developed numbness and weakness in her right lower extremity that spread to her right upper extremity and face. Brain MRI showed progression of subarachnoid lesion on FLAIR image and leptomeningeal enhancement on gadolinium-enhanced T1 weighted image. She was diagnosed as having rheumatoid meningitis, and methylprednisolone pulse therapy was started. Then, her symptoms and MRI findings were rapidly improved. Though rheumatoid meningitis is rare and presents a difficulty in the diagnosis, MRI features may support the diagnosis.
Full Text of this Article in Japanese PDF (549K)

(CLINICA NEUROL, 55: 926|931, 2015)
key words: rheumatoid meningitis, MRI, leptomeningitis

(Received: 22-Jun-15)