Rinsho Shinkeigaku (Clinical Neurology)

Progress of the Year 2014

Multiple system atrophy and autophagy

Koichi Wakabayashi, M.D., Ph.D.1) and Kunikazu Tanji, Ph.D.1)

1)Department of Neuropathology, Hirosaki University School of Medicine

Macroautophagy is a dynamic process whereby cytoplasmic molecules are sequestered within autophagosomes. There exist two groups of mammalian autophagy-related gene (Atg) 8 homologues (LC3 and GABARAPs), which play essential role in autophagosomal formation. We determined whether Atg8 homologues are affected in Lewy body disease (LBD) and multiple system atrophy (MSA). The level of LC3 was increased in an insoluble fraction from the brain of patients with LBD, whereas the level of GABARAPs was decreased in LBD. The level of matured GABARAPs was significantly decreased in the cerebellum of MSA, and that the higher levels of matured and lipidated LC3 were detected in detergent-insoluble fraction of MSA. Furthermore, immunohistochemical staining revealed that both LC3 and GABARAPs were localized in Lewy bodies and glial cytoplasmic inclusions in MSA were positive for LC3. These findings suggest that autophagic function is impaired through alteration of Atg8 homologues in LBD and MSA. Autophagy-enhancing strategies can therefore have therapeutic efficacy for various neurodegenerative diseases including LBD and MSA.
Full Text of this Article in Japanese PDF (215K)

(CLINICA NEUROL, 54: 966|968, 2014)
key words: autophagy, multiple system atrophy, Lewy body disease, Atg8, inclusion body

(Received: 22-May-14)