Rinsho Shinkeigaku (Clinical Neurology)

Symposium 30

Recent findings in dermatomyositis-specific autoantibodies

Manabu Fujimoto, M.D.1)

1)Department of Dermatology, Faculty of Medicine, University of Tsukuba

Recently, new autoantibodies specific for dermatomyositis have been identified, including anti-melanoma differentiation antigen 5 antibody, anti-transcriptional intermediary factor 1 antibody, and anti-nuclear matrix protein 1 antibody, in addition to those described previously such as anti-aminoacyl tRNA synthetase antibodies and anti-Mi-2 antibody. These disease-specific autoantibodies cover approximately 80% of the patients, and thus are useful for the diagnosis. Moreover, these antibodies are closely associated with specific disease phenotypes, and enable us to predict complications and prognosis and to evaluate disease activity.
Full Text of this Article in Japanese PDF (224K)

(CLINICA NEUROL, 54: 1110|1112, 2014)
key words: dermatomyositis, myositis-specific autoantibody, malignancy, interstitial lung disease

(Received: 24-May-14)